Police officials who spoke on campus at 3 p.m. today said that shots were fired on the campus and at least three people were injured.
"A person of interest has been detained," said Major Armando Tello of the Harris County Sherrif's Department.
Tello described the situation as "ongoing."
Two individuals with multiple gunshot wounds are in serious condition at Ben Taub Hospital according to KTRK-TV in Houston.
Emergency reponders are currently on campus.
Police were searching for a man described as 6-foot-2 and wearing a Atlanta Falcons cap, KTRK reported.
A statement on the school's website advised students and faculty to "shelter in place" wherever they are on campus. It gave no details of the shooting situation.
The shooting comes only a month after the massacre at Sandy Hook elementary school in Newtown, Conn., in which 20 students and six staff members were shot, sparking a wave of attempted copycat crimes in states like California and Indiana.
The Connecticut shooting inspired calls from government officials including President Obama for stricter gun control laws.